They reliably produce a clinically significant effect on weight with limited to trivial side effects, and doing so in a way that improves health beyond what would expected from the weight loss alone. We’re only starting to understand the range of additional benefits they are capable of producing. What is there to question?
That is actually not far from its mechanism of action. It profoundly changes a patients’ definition of “eating as much as you want” in ways that allow for the development of a much healthier weight and typically achieved with much healthier dietary practices
I understand the mechanism and that the drugs have disease relevant and concrete outcomes that are achieved safely. Hopefully be able to incorporate these as options that can be brought into play relatively early to maximise they impact throughout an individuals life time - but therein also lies a tricky conundrum, 5, 10 or 15, or 25 years of age? When?
In addition, we know that this will be an option for the 1st world earlier than those maybe more in need and outside the 1st world - and I’m not talking the difference between India and the US, but rather the differences between Maryhill and Bearsden in Glasgow.
Admittedly, some of the drugs may be close to going generic (though I have not specifically looked) which would facilitate their use in developing countries.
Arent these a completely set of questions/concerns? They are not insignificant questions to ask, but with the goal post shifting Im just trying to understand where you’re coming from.
Yes, I guess you are probably right about the thread drifting. My angst is the following:
I struggle with the riff, always have
I am one of those for whom an instance on the lips is, really, a lifetime on the hips
I want there to be a magic pill, sort of like this, but available to all who want it/need it (I will struggle on w/o it and claim a mind over matter victory until no circus mirror can hide it)
I still think taking it diminishes (the majority) us and feels like giving in - rather than just eating less
There is also the homage this sort of thing pays to the body beautiful vanity need - a personal image of perfection that can never be attained
The way I see it…before was paying £139 and getting 5th jab free, now I’m paying for 5th jab thanks to the increase.
Works out £34 a week per Jab.
Saving that on food and beer.
Yeah I did.
I bought 2 pens last week and only started the pen I already had last week - so 4 jabs left of that…Dont need to buy one until December now.
I think the patent for this is expiring soon. This is probably the drug company trying to milk as much money as possible before it does. Watch for more affordable priced variants coming out later.
I think the patents for Wegovy is scheduled to expire in March 2026 in India atleast. Expect those prices to come even further down once those medicines hit the general market.
This is an old drug class that we’ve been exploring its potential for weight loss since I was in grad school and so there are already generics available for Novo’s first version of the drug, Victoza (liraglutide vs semaglutide).
There was a really nice study published a few months ago of a direct head to head of Zepbound (Lilly) vs Wegovy (Novo, the weight loss specific version of Ozempic) that showed better results for Zepbound
One caveat is the time frame of the study is pretty long and speaks more to the sustainability of results rather than the sort of weight loss journey being described here. Second big caveat is this was a Lilly funded study. But the counter to that is that Lilly’s drug has a dual mechanism of actions which was created in part because of a hypothesis it would work better in the long term than the drugs that were just GLP-1 agonists
