I didn’t intend my post to be taken as as challenge to @Iftikhar. Sorry if it came over that way.
There’s been a lot of talk about herd immunity and I was just questioning if there was any evidence that it is a reality / possibility in the case of Covid 19.
If there isn’t (any evidence), then it is reckless for any government to take the gamble.
I think you can make an argument that whatever the factors were that made a place susceptible to a first wave spread, e.g. culture, demography, urban design, make it susceptible to a resurgence.
There an argument that the ones that were hit worst are more susceptible to lowering their guard once they seem to get it under control because the improvement is more tangible, and that leads to an over reaction and rebound, but NYC appears to be arguing against that, at least in terms of the broad strokes.
It was estimated that 6% of the population was infected during the 1st wave, this second wave looks more wide spread (in France) we could see double or triple so 18 to 24% at this rate at least 4 waves will be needed at a guess. That’s not taking into account how long immunity lasts or anything else just an extrapolation of estimated infection ‘rates’.
As this 2nd wave is soo wide spread we are now definitely in the realms of having herd immunity numbers eventually. The 1st wave was localised clusters for example the hot spot in France for this second wave (PACA) was hardly touched 1st wave.
Oddly enough in German debates the complete opposite argument is often made, the ‘there’s no glory in prevention’ point, where the most resistance against measures is often in areas that haven’t been hit hard at all, so hardly anyone knows anyone who’s had it (many parts of East Germany for example).
I’m also wondering what is so different about e.g. Italy vs Spain this time around (at the moment at least). Oh well, we’ll see…
Once approved they will still have to run real-world post-marketing trials (phase 4) on real patients. These studies are run to do a more robust safety analysis of how it is used in the real world, but are also often designed with a view to allowing them to expand their indication and label claim. So there is potential for one of these first movers to later demonstrate a more clinically relevant effect with the already approved drug.
The problem though is as you described, the public believing the early movers “work” will result in behaviors that will make the situation worse. That ranges from the discarding of social distancing etc to participants refusing to participate in the studies of the other vaccines still in development.
Aye, see my last post above, the Italy thing is part of what makes me wonder. I’d really like to find out what the reason for the difference between e.g. Italy and Spain is atm. Not sure there is an easy answer though.
Not terribly impressed with Sweden tbh, but probably best not get into that Sweden debate again
[quote=“Cologne-Liverpool, post:294, topic:346”]
Oddly enough in German debates the complete opposite argument is often made, the ‘there’s no glory in prevention’ point, where the most resistance against measures is often in areas that haven’t been hit hard at all, so hardly anyone knows anyone who’s had it (many parts of East Germany for example). [/quote] @Cologne-Liverpool tagging you as the quote got screwed up and Im seemingly unable to fix it.
Yeah, we see the same thing here - sheltered from the first wave, initial rejection of the concern and mitigation efforts then becomes entrenched even when that first wave eventually hits them.
But I do think that is a different effect than the tendency to let your guard down once you see tangible signs of improvement. The guy who owns my company is a Frenchman who now lives in NYC. In June when NYC first started opening back up he went to Paris to see his family. He lasted 1 day before he said fuck it and rented a villa in the country to get away from people because he just could not get his head around how lax everyone was being. But it is very much a celebratory “we beat this thing” sort of response. IF there is something about that specific place that explained why it got hit hard in the first wave other than luck, under those circumstances you would expect a big second wave.
I dont know if that explains it, and there are obviously a massive variety of different responses that we see even within a single population, but I see enough examples of that to suggest it might be contributing.
@Noo_Noo in addition to what you said, I want to add the Bangladesh experiment.
We started to remove the restrictions from May 31 and 300000 of the recorded infections happened after that. Number of tests were very low and the process was seriously discouraging for the people. Finally, we didn’t had any contact tracing mechanisms.
In short, too much were left to the chances or to the people to fend for themselves.
Daily death rate is now going up again. In most European countries, it has at least doubled since last week. That applies for the UK as well, admittedly starting from a low point (7 days-average of around 23 deaths a day now, compared to an average of 11 deaths a day last week, according to worldometer).
That’s above the pwak figure for the first wave according to the FT website. Obviously there’s differences in testing numbers but still a scary figure. Especially when you think they still aren’t anywhere near capturing all of those infected.