The Corona Pandemic

No I’am not, it’s going to be their problem.
The data you posted has signs of concern that even a half baked trial would have identified. I don’t care it’s not going to be my problem!

Just plainly not true. These reactions have occurred at a rate of less than 1 in 500,000. How many trials have a vaccinated cohort that big?!

Pharma,with a huge amount of public money, have done fantastic to get these vaccines to the stage of production in a very short time.But at the moment we are being hampered by their inability to keep up with demand.If we,and they,are thinking about the wider society,why aren’t there dozens,if not hundreds of facitities churning these vaccines out.

I guess production lines for such products are huge investments in terms of capital and resources and time to build up. And they might have the buildings but still it takes time to build up the equipment and technicalities to produce in big quantities. And even if there are overlapping capabilities, they cannot divert all resources to just produce this vaccine as realistically there are still plenty of medication needs for all types of illnesses and conditions around the world, they cannot drop all other needs just to cater for this vaccine. Maybe there are other reasons or considerations but this is what I think.

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There are plenty in pharma who already have the building,equipment and expertise to do this.Many of these companies do have the ability to divert their current production of medication to one of their other facilities for a short period until this initial shortfall in vaccine is overcome.Ther current owners of these vaccines hold the patents and won’t share them for the greater good to rid us as best as possible of this virus.In the long run they want to make their money.

I am sure commercial consideration is a huge factor too. I think so far AZ is the only pharma that agreed generally to transfer the knowledge at cost, is that right? The rest are still selling it with commercial contract negotiations right?

Afaik they are selling the product at cost,not transferring the knowledge.

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I don’t get your point. I haven’t seen it said anywhere you shouldn’t get a jab if you’ve had the virus, even quite recently.

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Quite the opposite in fact. The advice is to get it.

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IgA nephropathy or Bergers disease for me. IgA is a protein produced by the immune system to fight viruses and the like. Mine are slightly defective and decide to settle in the kidneys and basically block the system causing swelling and ultimately scarring.

So taking something that is designed to produce anti bodies, the very thing that is killing me was a worry. But on reflection far better to be vaccinated in a controlled manner instead of gambling that I don’t catch it and my immune response goes into overdrive which has been reported with Covid.

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They have. That’s how it’s being produced in 15 different countries across at least 4 continents and currently sold at cost everywhere.

We are heading into another lockdown from Monday.

Are they all producing the drug substance? I thought only limited sites where doing this.

I’m not sure about the specifics as to the split between drug substance manufacture and vaccine production (to include fill and finish) but drug substance is being manufactured in at least six countries (across 4 continents) that I know of. UK, Belgium, Netherlands, USA, Argentina, and India.

Outside of the UK, 5 sites to supply the world, one of which(halix) has had questions about it and only this last week been approved to make the drug. Not exactly churning the stuff out as yet.

At least 5 sites. Globally more than 200 million doses have so far been produced, second only to Pfizer.

I thought it was more than that(200million)tbh.

It is but I’m being conservative rather than overestimating and getting it wrong.

Very Conservative I would say, but I still think that once manufacturing started they should have produced more.India look to be putting the other sites to shame.

Yes, very conservative but then I wouldn’t want to be accused of being nationalistic by trumpeting the actual contribution of the AstraZeneca vaccine, would I? :wink:

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